• Fig shows the percentage of patients

  2019-05-08

  

  Fig. 2 shows the percentage of patients with high D-dimer levels in relation to the CHA2DS2–VASc scores and BNP levels. None of the patients had a CHA2DS2–VASc score of 0. The BNP levels were elevated in 3 (38%) of the 8 patients with CHA2DS2–VASc scores of 1, and the D-dimer levels were elevated in

• Numerous animal studies have demonstrated beyond

  2019-05-08

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• br Discussion Zoledronic acid has been approved for preventi

  2019-05-08

  

  Discussion Zoledronic Okadaic acid has been approved for prevention and treatment of osteoporosis and glucocorticoids-induced osteoporosis, treatment of Paget\'s disease, hypercalcemia, multiple myeloma and bone metastasis. In the particular case of breast cancer, it is recommended as a monthly

• Extensive vascularization of the skeletal tissue

  2019-05-08

  

  Extensive vascularization of the skeletal tissue suggests the importance of blood vessels in regulating its physiological functions. Endothelium, the innermost cellular layer of blood vessels forms a central component of the bone marrow vascular microenvironment [7]. Recent evidence support that a p

• Emergency care inherently addresses the wide array of illnes

  2019-05-07

  

  Emergency care inherently addresses the wide array of illness and injury, including traumatic injuries, surgical disease, acute complications of chronic illness (eg, strokes, myocardial infarction, diabetic ketoacidosis, complications of HIV, tuberculosis, hepatitis C, and other chronic infections),

• The majority of breast malignancies

  2019-05-07

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• The first variant in the non spine topic

  2019-05-07

  

  The first variant in the non-spine topic describes a patient with an excellent performance status, a favorable life expectancy, and an asymptomatic Epinephrine Bitartrate cost lesion which does not pose an obvious risk for pathologic fracture. While the authors acknowledge that research has begun t

• br Conflict of interest br Authors contributions br

  2019-05-07

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• br Introduction Atrial fibrillation AF is the most

  2019-05-07

  

  Introduction Atrial fibrillation (AF) is the most clinically prevalent tachyarrhythmia [1,2]. AF is a potential risk factor for stroke, and AF-associated strokes are often severe, resulting in disability or death [3–6]. Anticoagulant therapy with the vitamin K antagonist warfarin reduces the risk

• Now consider a Special Report by

  2019-05-07

  

  Now consider a Special Report by the WHO Ebola Response Team. In it, the authors rightly—if not tautologically—suggest that shortening the delay to isolation of Ebola virus disease suspects would lead to quicker overall outbreak containment, yet they fail to adequately discuss the reality that suspe

• Preventive chemotherapy for schistosomiasis is rapidly

  2019-05-07

  

  Preventive chemotherapy for schistosomiasis is rapidly scaling up worldwide. The global coverage that was less than 10% in 2010 is now higher than 30%, however, the main limitation for the scaling up is the availability of donated drug. In school age children, the age group for which praziquantel is

• Despite these recommendations diagnosing CIED infection

  2019-05-07

  

  Despite these recommendations, diagnosing CIED infection could be challenging. Early after implantation procedure it is important to differentiate CIED pocket infection from incisional erythema or superficial wound infection or stitch abscess. These cases usually resolve with local measures and some

• Although no GWAS results have been reported

  2019-05-07

  

  Although no GWAS results have been reported so far from Asian populations, the candidate gene approach identified SNPs in 4q25 and 1q21 as being associated with AF in Asian populations [19,20]. Conflicting data are reported in terms of 16q22; it is associated with AF in Chinese Han [37], but not in

• br Commentary Recordings of the activation sequence from the

  2019-05-07

  

  Commentary Recordings of the activation sequence from the CS during tachycardia are expected to help discriminate among atrial tachyarrhythmias [2]. During ongoing typical CCW AFL, most of the CS is activated from proximal to distal, because the CS musculature, by being continuous with the RA myo

• Since many decades bone tumours have

  2019-05-07

  

  Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh

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